Programme

• Tuesday, 11 June

  11:00-19:00	Opening & Registration
  13:00	Welcome Magnifico Rettore dell’Alma Mater Studiorum - Università di Bologna Direttore Generale della Fondazione Golinelli Valeria Poli Giovanni Capranico
  	Functional diversity of DNA repair mechanisms CHAIRS:  Philip Avner and Fabiola Moretti
  13:15-13:45	Marco Foiani, IFOM, Milan, Italy Mechanisms coordinating replication and transcription
  13:45-14:15	EMBL Lecture Julian Sale, MRC Laboratory of Molecular Biology, Cambridge, UK Monitoring replication of DNA secondary structures through the lens of the epigenome
  14:15-14:45	Philippe Pasero, CNRS, Université de Montpellier, France Spontaneous replication stress as a source of genomic instability and inflammation in cancer
  14:45-15:15	ABCD Lecture Yves Pommier, NIH, National Cancer Institute, Bethesda, USA Schlafen 11: a native immune response gene engaged by DNA damage and replication stress
  15:15-15:45	Coffee break
  15:45-16:15	Armenise Lecture Vincenzo Costanzo, IFOM, Milan, Italy BRCA1, BRCA2 and RAD51: the guardians of vertebrate genome stability
  16:15-17:00	Talks selected from abstracts Stefano Amente, University of Naples "Federico II", Italy Genome-wide mapping of 8-oxo-7,8-dihydro-2'-deoxyguanosine reveals accumulation of oxidatively-generated damage at the promoter regions of transcribed genes in human genome
  	Giulia Nava, University of Milan, Italy RNase H activities counteract a toxic effect of Polymerase η in cells replicating with depleted dNTP pools
  	Roberto Giambruno, IEO, Milan, Italy Protein arginine methyltransferase 1 (PRMT1) promotes senescence-associated secretory phenotype (SASP) in response to DNA damage
  17:00-18:30	Poster Session 1 (odd numbers)
  18:30-20:30	Science and Society CHAIRS:  Valeria Poli and Gennaro Ciliberto
  	Human Technopole and the future of Italian research Round table Panelists: Dr Iain Mattaj, Director of the Human Technopole Foundation in Milan Prof. Valeria Poli, President of SIBBM Prof. Gennaro Ciliberto, Direttore Scientifico Istituto Regina Elena, Board of Directors-ACC (Alleanza Contro il Cancro), President FISV (Federazione Italiana Scienze della Vita) Dr Manuela Battaglia, Telethon Chief Scientific Officer Prof. Salvatore Sciacchitano, Ministry of Health The opening will be by Iain Mattaj, 15-20’, presenting the plans for the Human Technopole and its relationships with the rest of Italian biomedical research. Then the other panelists will expose their ideas about the matter (5-10’). A round of replies will follow, 5 minutes maximum /each, and finally Q&A from the audience and public discussion. This Session is for a general audience and will be streamed live on YouTube
  20:30	Light dinner and meet-the-speaker
  23:00	Shuttle to Bologna city centre

• Wednesday, 12 June

  	Nucleic acid sensing: from microbes to eukaryotes CHAIRS:  Valeria Poli and Marco Muzi Falconi
  8:30-8:40	Introduction to Riccardo Cortese Lecture by Valeria Poli
  8:40-9:10	Riccardo Cortese Lecture Francisco Mojica, Universidad de Alicante, Spain CRISPR immunization
  9:10-9:40	Gabriella Campadelli-Fiume, University of Bologna, Italy Oncolytic viruses heat the immune-cold tumors
  9:40-10:10	EMBO Young Investigator Lecture Jan Rehwinkel, University of Oxford, UK SAMHD1 at the crossroads of nucleotide metabolism and cell death
  10:10-10:55	Talks selected from abstracts Mila Gugnoni, IRCCS, Reggio Emilia, Italy RUNX2 in cancer progression: regulation and mechanisms of action
  	Eva Bartok, University Hospital Bonn, Germany Endosomal RNases regulate the innate immune response to TLR7 and TLR8
  	Simone Sabbioneda, CNR, Pavia, Italy UBR5 interacts with the replication fork and protects DNA replication from DNA polymerase η toxicity
  10:55-11:15	Coffee break
  11:15-12:00	Premio Chiara D’Onofrio Diego Pasini, IEO and University of Milan, Italy Epigenetic control of cell identity by chromatin modifiers
  12:00-13:30	Poster Session 2 (even numbers)
  13:30-14:15	Lunch
  	Epitranscriptome, RNA editing and new technologies CHAIRS:  Giulio Pavesi and Salvatore Oliviero
  14:15-14:45	Kazuko Nishikura, The Wistar Institute, Philadelphia, USA Regulation of R-loop formation and genome stability by ADAR RNA editing enzymes
  14:45-15:15	Giancarlo Mauri, University of Milano Bicocca, Italy Modelling and data integration in cancer research
  15:15-15:25	Gold sponsor Menarini Ricerche S.p.A. Giuseppe Merlino MEN1309/OBT076, a first-in-class Antibody-Drug-Conjugate (ADC) targeting CD205 in solid tumors
  15:25-15:55	Rosalba Giugno, University of Verona, Italy Network approaches to multi-omics analysis of complex diseases
  15:55-16:25	Coffee break
  16:25-16:55	Anna Cereseto, University of Trento, Italy From user- to genome-friendly CRISPR-Cas
  16:55-17:40	Talks selected from abstracts Matteo Chiara, University of Milan, Italy Comparative assessment of the sequencing biases of SMRT and ONT sequencing technologies
  	Isaia Barbieri, University of Cambridge, UK METTL1 promotes let-7 microRNA processing via m7G methylation
  	Lisa Marie Simon, University of Turin, Italy In vivo analysis of the influenza A mRNA secondary structure landscape identifies critical regulatory motifs
  17:40-18:40	Poster session 1 & 2
  18:40-20:00	General annual assembly of SIBBM (reserved to members)
  20:45	Social dinner in downtown Bologna

• Thursday, 13 June

  	Nucleic acid sensing and immune response in diseases CHAIRS:  Tiziana Bonaldi and Giovanni Capranico
  8:30-9:00	Mario P. Colombo, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Neutrophils- and lymphocytes-released DNA threads in cancer and autoimmunity
  9:00-9:30	Gunther Hartmann, University of Bonn, Germany RIG-I-induced innate immune memory
  9:30-10:30	Talks selected from abstracts Antonio Totaro, University of Padua, Italy Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ-mechanotransduction
  	Federica Marasca, INGM, Milan, Italy LINE1 enriched chromatin RNAs govern T lymphocytes’ identity and functions
  	Lisa Wiesmueller, Ulm University, Germany Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1
  	Francesca Pisani, CNR, Naples, Italy Coupling DNA replication to sister chromatid cohesion: the role played by the Warsaw breakage syndrome DNA helicase DDX11/ChlR1 and the replication fork-protection factor Timeless
  10:30-11:30	Coffee break
  11:30-12:00	Martin Reijns, University of Edinburgh, UK Combatting the enemy within: intracellular surveillance of genome instability
  12:00-12:30	Marco E. Bianchi, University Vita-Salute San Raffaele, Milan Activated macrophages eject histones associated to the outer surface of microvesicles
  12:30-12:50	Prizes, Travel grants and Farewell

• POSTERS

  When preparing your poster, please remember that its maximum size is 1 x 1.4 m (width x height). Note that the orientation is portrait, not landscape.

  Correct format...    Wrong format...

  Posters will be on display for the entire duration of the meeting. Posters with an odd number will be presented during Poster Session I (Tuesday, 11 June). Posters with an even number will be presented during Poster Session II (Wednesday, 12 June). Posters can be mounted on Tuesday, 11 June, and must be removed on Thursday, 13 June, before 12:00.

  P.1 Alessandra Agresti, Milan
  LPS-challenged macrophages release microvesicles coated with histones

  P.2 Katarzyna Andryka, Bonn, Germany
  Chemotherapeutics drugs induce DNA modifications which potentiate cGAS activation

  P.3 Lidia Avalle, Turin
  STAT3 transcriptional targets mediate the cross-talk between cancer associated fibroblasts and tumor cells conferring aggressiveness to mammary tumors

  P.4 Dario Balestra, Ferrara
  Rescue of multiple Haemophilia A-causing mutations by a single ExSpeU1: the importance of the genomic context

  P.5 Stefano Barbera, Siena
  The small GTPase Rab5c regulates the trafficking of the CD93/Multimerin-2/ß1 integrin complex during endothelial cell adhesion and migration

  P.6 Giovannina Barisciano, Benevento
  Identification of new biomarkers for early diagnosis and targeted treatments in breast cancer by engineered optical fibers (lab in needle)

  P.7 Desiree Baruffaldi, Turin
  ESDN expression in the tumor microenvironment coordinates melanoma progression

  P.8 Ylenia Beniamino, Bologna
  Structural and biophysical characterization of SrnR, a protein involved in the nickel responsive transcriptional regulation of sodF from Streptomyces griseus

  P.9 Sofia Bertone, Turin
  Chimeric axl-miR-214sponge aptamers as tumor dissemination blocking tools

  P.10 Elena Carbognin, Padua
  Study of the irreversible exit from naïve pluripotency in mouse Embryonic Stem cells

  P.11 Valeria Cavaliere, Bologna
  In vivo analysis of human Tdp1^H493R mutant in a Drosophila model of SCAN-1 disease

  P.12 Roberto Ciaccio, Bologna
  The novel long non-coding RNA RP1X cooperates to N-Myc stabilization and poor prognosis in high-risk neuroblastoma

  P.13 Anastasia Conti, Milan
  A DNA damage response dependent inflammatory program in human hematopoietic stem cells following gene editing

  P.14 Giacomo Corleone, Rome
  Epigenomic dissection of oestrogen receptor-positive breast cancer reveals novel cancer key players and principles of enhancers plasticity

  P.15 Lucia Coscujuela Tarrero, Orbassano (TO)
  CDYL circularizing exon involved in luminal breast cancer cell survival

  P.16 Francesca Cutruzzolà, Rome
  The RNA-binding moonlighting function of the metabolic enzyme serine hydroxymethyltransferase links nucleotide and serine metabolism in lung cancer cells

  P.17 Dario Dattilo, Rome
  Role of N6-methyladenosine in the biogenesis and function of circular RNAs

  P.18 Vito De Pinto, Catania
  Microarray analysis of a S. cerevisiae strain devoid of porin1 (yVDAC1) reveals the regulatory function of the pore

  P.19 Genny Degani, Milan
  MS-identification of prothrombin as a potential new interactor of the human receptor for advanced glycation end products (RAGE)

  P.20 Giulia Della Chiara, Milan
  Dissecting the epigenetic landscape of colorectal cancer by exploiting the organoids model

  P.21 Lucia Falbo, Milan
  Epigenetic control of DNA replication origin assembly regulates vertebrate development and nuclear reprogramming

  P.22 Giulio Ferrero, Turin
  Small RNA profiles in human stool reflect gut microbiome composition and together provide high accuracy to detect colorectal cancer

  P.23 Sebastian Franco Ulloa, Genoa
  Functionalized gold nanoparticles cellular uptake in the presence of various organic coatings

  P.24 Guendalina Froechlich, Naples
  Elucidation of tumor cell-expressed STING function into HSV-1 based oncolytic virotherapy

  P.25 Chiara Gabellini, Pisa
  CRISPR/Cas9-induced inactivation of the autism risk gene setd5, a putative chromatin regulator, leads to neurotransmission-associated gene alterations and social impairments in zebrafish

  P.26 Francesco Ghini, Reggio Emilia
  Context makes difference: the tumor suppressor E2F7 behaves as oncogene in undifferentiated epithelial cancers

  P.27 Sabrina Giantulli, Rome
  In vitro biological effects induced by the ultrasound-cell interaction

  P.28 Anna Maria Sole Giordano, Milan
  Generation of in vitro models of the Aicardi-Goutières Syndrome to dissect mechanisms of physiopathology

  P.29 Federico Giorgi, Bologna
  Pan-Cancer and Single-Cell modelling of genomic alterations through gene expression

  P.30 Francesca Guarino, Catania
  Human VDAC isoforms promoters: bioinformatic characterization and activity modifications in metabolic stress condition

  P.31 Jessica Guerra, Montpellier, France
  DRIP75 produces a second messenger to curb STING-dependent inflammation

  P.32 Lorena Kumarasinghe, Pozzuoli (NA)
  Understanding the pathological mechanism that leads to the cellular defects in Vici syndrome

  P.33 Hulyam Kurt, Eskişehir, Turkey
  The role of functional polymorphism located in MMP-9 gene promoter with schizophrenia patients

  P.34 Silke Lambing, Bonn, Germany
  Enhanced combinatorial efficacy of RIG-I mediated immunotherapy and radiotherapy in malignant melanoma

  P.35 Federico Lazzaro, Milan
  VID22 as a new palyer in the maintenance of genome integrity at G-quadruplex loci

  P.36 Irene Liparulo, Bologna
  Coenzyme Q depletion induces a change in chemical-physical properties of the plasma membrane

  P.37 Federica Lucini, Milan
  A novel technological approach to explore chromatin higher order structures in CD4⁺ T cells

  P.38 Giuseppe Madaro, Pisa
  Disentangle the link between nuclear Tau and gene expression regulation

  P.39 Alessandro Maglione, Orbassano (TO)
  Integrative analysis of -omic data reveals estrogen-responsive genomic regions in T helper cell plasticity

  P.40 Paolo Malatesta, Genoa
   Immunovirotherapy eradicates glioblastoma in a preclinical model

  P.41 Monica Mancini, Busto Arsizio
  Investigating the role of UHRF1 depletion in the sensitization to DNA damage following treatment with the DNA demethylating agent 5-aza-2’-deoxycytidine

  P.42 Marcella Manerba, Genoa
  A chemical biology approach to synthetic lethality by means of DNA repair inhibitors

  P.43 Giovanna Mangiapane, Udine
  Characterisation of APE1 paracrine function in hepatocellular cancer cells

  P.44 Chiara Marabelli, Pavia
  A tail-based mechanism drives nucleosome demethylation by the LSD2/NPAC multimeric complex

  P.45 Jessica Marinello, Bologna
  Development of new G4 binders in cancer therapy: synthesis, biophysical and biological studies of hydrazones derivatives

  P.46 Federica Marini, Milan
  The scaffold protein SLX4/FANCP plays a conserved role in early steps of homologous recombination DNA repair

  P.47 Samira Marx, Bonn, Germany
  A minimal RNA secondary structure motif mediates potent and selective activation of TLR7

  P.48 Enrico Massignani, Milan
  hmSEEKER: reliable identification of methyl-peptides from computational analysis of hmSILAC mass spectrometry data

  P.49 Valentina Menetti, Monterenzio (BO)
  Modulation of LINE-1 retrotransposition by Aicardi-Goutières Syndrome-Related RNase H2

  P.50 Giulia Miglietta, Bologna
  G4 binders as new potential immunostimulatory compounds by micronuclei induction and cGAS-STING pathway activation in human cancer cells

  P.51 Stefano Miglietta, Bologna
  MCJ/DNAJC15: role in mitochondrial metabolism of chemoresistant ovarian cancer cells

  P.52 Barbara Montanini, Parma
  New antimicrobials targeting bacterial RNA polymerase holoenzyme assembly identified with an in vivo BRET-based discovery platform

  P.53 Emanuele Monteleone, Turin
  STAT3-dependent pluripotency control via the stem-cell specific long non-coding RNA lincS1

  P.54 Sara Monticelli, Bologna
  Maximal increase of MYC to MAX expression ratio in the Drosophila eye triggers the eye to wing homeotic transformation, through deregulation of HOX genes expression

  P.55 Luisa Napolitano, Basovizza (TS)
  Human RecQ4 helicase shows DNA:RNA hybrids resolving activity

  P.56 Silvia Onesti, Trieste
  Structural insights into the evolution of the Cdc45 replication factor and its role within the  replicative helicase complex

  P.57 Francesca Orso, Turin
  miR-214 in tumor-stroma cell interactions

  P.58 Simona Paglia, Bologna
  A neurogenic model of adult brain cancer in Drosophila

  P.59 Alessandra Pagliarani, Ozzano Emilia (BO)
  Molecular clues shoulder the involvement of the mitochondrial Ca²⁺-activated F₁F_O-ATPase in the permeability transition pore

  P.60 Tito Panciera, Padua
  Mechanobiology of YAP and TAZ in physiology and disease

  P.61 Elvira Parrotta, Catanzaro
  Comprehensive proteogenomic analysis of human embryonic and induced pluripotent stem cells

  P.62 Graziano Pesole, Bari
  Characterization of expanded short tandem repeats related to genetic disorders through Oxford Nanopore Technology long read native DNA sequencing

  P.63 Sabrina Petralla, Bologna
  Proliferation/differentiation dysregulation in AGC1 deficiency brain precursor cells

  P.64 Giulia Piaggio, Rome
  Of mice and Zebrafish: shedding light for oncology research

  P.65 Ernesto Picardi, Bari
  Elucidating thousand RNA human editomes through a novel HPC REDItools algorithm

  P.67 Lorena Quirico, Turin
  Axl-148b aptamer inhibits melanoma and breast cancer tumor progression

  P.68 Cristina Renna, Milan
  The Nuclear Mitotic Apparatus protein NuMA is a mitotic dynein/dynactin adaptor

  P.69 Patrizia Romani, Padua
  Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP

  P.70 Davide Roncarati, Bologna
  Molecular characterization of the heat-shock regulatory circuit in Campylobacter jejuni

  P.71 Marco Russo, Bologna
  Innate immune response genes in human cancers: a PanCancer survey

  P.72 Erica Salvati, Rome
  TRF1 Poly ADP-ribosylation by PARP1 is required for the accomplishment of telomere replication

  P.73 Aurora Savino, Turin
  Network analysis allows to unravel breast cancer molecular features and to identify novel targets

  P.74 Stefania Scalise, Catanzaro
  In vitro model of febrile seizures in patient-specific induced pluripotent stem cells-derived neurons

  P.75 Luana Scaramuzzino, Catanzaro
  No evidence of significant differences in oocytes development and follicular fluid miRNomic profile after double stimulation in the same ovarian cycle

  P.76 Fabrizio Schipani, Milan
  Inhibiting RAD51-mediated homologous recombination for cancer therapy

  P.77 Diletta Siciliano, Naples
  Analysis of the physiological relevance of TFEB phosphorylation in vivo

  P.78 Ottavia Tartagni, Bologna
  Reproducible growth of 3D cell spheroids for drug testing

  P.79 Didem Turgut Cosan, Eskişehir, Turkey
  Changes in levels of some microRNAs of rats in enriched environment after experimental subarachnoid hemorrhage

  P.80 Marta Viggiano, Bologna
  Whole exome sequencing analysis in a twin family with ASD

  P.81 Megi Vllahu, Fisciano (SA)
  The impact of copper on host-Helicobacter interaction

  P.82 Anja Wieland, Bonn, Germany
  Identification and functional analysis of potent TLR7- and TLR8-specific RNA oligonucleotide agonists for immunotherapy

  P.83 Samuel Zambrano, Milan
  NF-κB dynamics modulates stochastic but prompt transcriptional bursts in response to inflammatory stimuli

  P.84 Annamaria Zannoni, Bologna
  Study of HP1043, the Helicobacter pylori essential transcriptional regulator

  P.85 Pasquale Zizza, Rome
  Identification of a TRF2-driven miRNA signature in colorectal cancer

  P.86 Alessandro Zuccotti, Rome
  Eukaryotic Elongation Factor 2 kinase, activated in the response to ribosomal stress, is a novel target of the oncogenic PIM1 kinase