SIBBM 2019 • Frontiers in Molecular Biology

SIBBM 2019
Frontiers in Molecular Biology

11-13 June, Bologna

12-14 June

Società Italiana di Biofisica e Biologia Molecolare

Società Italiana di Biofisica
e Biologia Molecolare

Bologna, 11-13 June 2019


  • Tuesday, 11 June

    11:00-19:00 Opening & Registration
    13:00 Welcome
    Magnifico Rettore dell’Alma Mater Studiorum - Università di Bologna
    Direttore Generale della Fondazione Golinelli
    Valeria Poli
    Giovanni Capranico
      Functional diversity of DNA repair mechanisms
    CHAIRS:  Philip Avner and Fabiola Moretti
    13:15-13:45 Marco Foiani, IFOM, Milan, Italy
    Mechanisms coordinating replication and transcription
    13:45-14:15 EMBL Lecture
    Julian Sale, MRC Laboratory of Molecular Biology, Cambridge, UK
    Monitoring replication of DNA secondary structures through the lens of the epigenome
    14:15-14:45 Philippe Pasero, CNRS, Université de Montpellier, France
    Spontaneous replication stress as a source of genomic instability and inflammation in cancer
    14:45-15:15 ABCD Lecture
    Yves Pommier, NIH, National Cancer Institute, Bethesda, USA
    Schlafen 11: a native immune response gene engaged by DNA damage and replication stress
    15:15-15:45 Coffee break
    15:45-16:15 Armenise Lecture
    Vincenzo Costanzo, IFOM, Milan, Italy
    BRCA1, BRCA2 and RAD51: the guardians of vertebrate genome stability
    16:15-17:00 Talks selected from abstracts
    Stefano Amente, University of Naples "Federico II", Italy
    Genome-wide mapping of 8-oxo-7,8-dihydro-2'-deoxyguanosine reveals accumulation of oxidatively-generated damage at the promoter regions of transcribed genes in human genome
      Giulia Nava, University of Milan, Italy
    RNase H activities counteract a toxic effect of Polymerase η in cells replicating with depleted dNTP pools
      Roberto Giambruno, IEO, Milan, Italy
    Protein arginine methyltransferase 1 (PRMT1) promotes senescence-associated secretory phenotype (SASP) in response to DNA damage
    17:00-18:30 Poster Session 1 (odd numbers)
    18:30-20:30 Science and Society
    CHAIRS:  Valeria Poli and Gennaro Ciliberto
      Human Technopole and the future of Italian research
    Round table Panelists:
    Dr Iain Mattaj, Director of the Human Technopole Foundation in Milan
    Prof. Valeria Poli, President of SIBBM
    Prof. Gennaro Ciliberto, Direttore Scientifico Istituto Regina Elena, Board of Directors-ACC (Alleanza Contro il Cancro), President FISV (Federazione Italiana Scienze della Vita)
    Dr Manuela Battaglia, Telethon Chief Scientific Officer
    Prof. Salvatore Sciacchitano, Ministry of Health
    The opening will be by Iain Mattaj, 15-20’, presenting the plans for the Human Technopole and its relationships with the rest of Italian biomedical research. Then the other panelists will expose their ideas about the matter (5-10’). A round of replies will follow, 5 minutes maximum /each, and finally Q&A from the audience and public discussion.
    This Session is for a general audience and will be streamed live on YouTube
    20:30 Light dinner and meet-the-speaker
    23:00 Shuttle to Bologna city centre
  • Wednesday, 12 June

      Nucleic acid sensing: from microbes to eukaryotes
    CHAIRS:  Valeria Poli and Marco Muzi Falconi
    8:30-8:40 Introduction to Riccardo Cortese Lecture by Valeria Poli
    8:40-9:10 Riccardo Cortese Lecture
    Francisco Mojica, Universidad de Alicante, Spain
    CRISPR immunization
    9:10-9:40 Gabriella Campadelli-Fiume, University of Bologna, Italy
    Oncolytic viruses heat the immune-cold tumors
    9:40-10:10 EMBO Young Investigator Lecture
    Jan Rehwinkel, University of Oxford, UK
    SAMHD1 at the crossroads of nucleotide metabolism and cell death
    10:10-10:55 Talks selected from abstracts
    Mila Gugnoni, IRCCS, Reggio Emilia, Italy
    RUNX2 in cancer progression: regulation and mechanisms of action
      Eva Bartok, University Hospital Bonn, Germany
    Endosomal RNases regulate the innate immune response to TLR7 and TLR8
      Simone Sabbioneda, CNR, Pavia, Italy
    UBR5 interacts with the replication fork and protects DNA replication from DNA polymerase η toxicity
    10:55-11:15 Coffee break
    11:15-12:00 Premio Chiara D’Onofrio
    Diego Pasini, IEO and University of Milan, Italy
    Epigenetic control of cell identity by chromatin modifiers
    12:00-13:30 Poster Session 2 (even numbers)
    13:30-14:15 Lunch
      Epitranscriptome, RNA editing and new technologies
    CHAIRS:  Giulio Pavesi and Salvatore Oliviero
    14:15-14:45 Kazuko Nishikura, The Wistar Institute, Philadelphia, USA
    Regulation of R-loop formation and genome stability by ADAR RNA editing enzymes
    14:45-15:15 Giancarlo Mauri, University of Milano Bicocca, Italy
    Modelling and data integration in cancer research
    15:15-15:25 Gold sponsor Menarini Ricerche S.p.A.
    Giuseppe Merlino
    MEN1309/OBT076, a first-in-class Antibody-Drug-Conjugate (ADC) targeting CD205 in solid tumors
    15:25-15:55 Rosalba Giugno, University of Verona, Italy
    Network approaches to multi-omics analysis of complex diseases
    15:55-16:25 Coffee break
    16:25-16:55 Anna Cereseto, University of Trento, Italy
    From user- to genome-friendly CRISPR-Cas
    16:55-17:40 Talks selected from abstracts
    Matteo Chiara, University of Milan, Italy
    Comparative assessment of the sequencing biases of SMRT and ONT sequencing technologies
      Isaia Barbieri, University of Cambridge, UK
    METTL1 promotes let-7 microRNA processing via m7G methylation
      Lisa Marie Simon, University of Turin, Italy
    In vivo analysis of the influenza A mRNA secondary structure landscape identifies critical regulatory motifs
    17:40-18:40 Poster session 1 & 2
    18:40-20:00 General annual assembly of SIBBM (reserved to members)
    20:45 Social dinner in downtown Bologna
  • Thursday, 13 June

      Nucleic acid sensing and immune response in diseases
    CHAIRS:  Tiziana Bonaldi and Giovanni Capranico
    8:30-9:00 Mario P. Colombo, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Neutrophils- and lymphocytes-released DNA threads in cancer and autoimmunity
    9:00-9:30 Gunther Hartmann, University of Bonn, Germany
    RIG-I-induced innate immune memory
    9:30-10:30 Talks selected from abstracts
    Antonio Totaro, University of Padua, Italy
    Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ-mechanotransduction
      Federica Marasca, INGM, Milan, Italy
    LINE1 enriched chromatin RNAs govern T lymphocytes’ identity and functions
      Lisa Wiesmueller, Ulm University, Germany
    Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1
      Francesca Pisani, CNR, Naples, Italy
    Coupling DNA replication to sister chromatid cohesion: the role played by the Warsaw breakage syndrome DNA helicase DDX11/ChlR1 and the replication fork-protection factor Timeless
    10:30-11:30 Coffee break
    11:30-12:00 Martin Reijns, University of Edinburgh, UK
    Combatting the enemy within: intracellular surveillance of genome instability
    12:00-12:30 Marco E. Bianchi, University Vita-Salute San Raffaele, Milan
    Activated macrophages eject histones associated to the outer surface of microvesicles
    12:30-12:50 Prizes, Travel grants and Farewell

    When preparing your poster, please remember that its maximum size is 1 x 1.4 m (width x height). Note that the orientation is portrait, not landscape.

    Correct format... poster should be PORTRAIT  poster should NOT be LANDSCAPE Wrong format...

    Posters will be on display for the entire duration of the meeting. Posters with an odd number will be presented during Poster Session I (Tuesday, 11 June). Posters with an even number will be presented during Poster Session II (Wednesday, 12 June). Posters can be mounted on Tuesday, 11 June, and must be removed on Thursday, 13 June, before 12:00.

    P.1 Alessandra Agresti, Milan
    LPS-challenged macrophages release microvesicles coated with histones

    P.2 Katarzyna Andryka, Bonn, Germany
    Chemotherapeutics drugs induce DNA modifications which potentiate cGAS activation

    P.3 Lidia Avalle, Turin
    STAT3 transcriptional targets mediate the cross-talk between cancer associated fibroblasts and tumor cells conferring aggressiveness to mammary tumors

    P.4 Dario Balestra, Ferrara
    Rescue of multiple Haemophilia A-causing mutations by a single ExSpeU1: the importance of the genomic context

    P.5 Stefano Barbera, Siena
    The small GTPase Rab5c regulates the trafficking of the CD93/Multimerin-2/ß1 integrin complex during endothelial cell adhesion and migration

    P.6 Giovannina Barisciano, Benevento
    Identification of new biomarkers for early diagnosis and targeted treatments in breast cancer by engineered optical fibers (lab in needle)

    P.7 Desiree Baruffaldi, Turin
    ESDN expression in the tumor microenvironment coordinates melanoma progression

    P.8 Ylenia Beniamino, Bologna
    Structural and biophysical characterization of SrnR, a protein involved in the nickel responsive transcriptional regulation of sodF from Streptomyces griseus

    P.9 Sofia Bertone, Turin
    Chimeric axl-miR-214sponge aptamers as tumor dissemination blocking tools

    P.10 Elena Carbognin, Padua
    Study of the irreversible exit from naïve pluripotency in mouse Embryonic Stem cells

    P.11 Valeria Cavaliere, Bologna
    In vivo analysis of human Tdp1H493R mutant in a Drosophila model of SCAN-1 disease

    P.12 Roberto Ciaccio, Bologna
    The novel long non-coding RNA RP1X cooperates to N-Myc stabilization and poor prognosis in high-risk neuroblastoma

    P.13 Anastasia Conti, Milan
    A DNA damage response dependent inflammatory program in human hematopoietic stem cells following gene editing

    P.14 Giacomo Corleone, Rome
    Epigenomic dissection of oestrogen receptor-positive breast cancer reveals novel cancer key players and principles of enhancers plasticity

    P.15 Lucia Coscujuela Tarrero, Orbassano (TO)
    CDYL circularizing exon involved in luminal breast cancer cell survival

    P.16 Francesca Cutruzzolà, Rome
    The RNA-binding moonlighting function of the metabolic enzyme serine hydroxymethyltransferase links nucleotide and serine metabolism in lung cancer cells

    P.17 Dario Dattilo, Rome
    Role of N6-methyladenosine in the biogenesis and function of circular RNAs

    P.18 Vito De Pinto, Catania
    Microarray analysis of a S. cerevisiae strain devoid of porin1 (yVDAC1) reveals the regulatory function of the pore

    P.19 Genny Degani, Milan
    MS-identification of prothrombin as a potential new interactor of the human receptor for advanced glycation end products (RAGE)

    P.20 Giulia Della Chiara, Milan
    Dissecting the epigenetic landscape of colorectal cancer by exploiting the organoids model

    P.21 Lucia Falbo, Milan
    Epigenetic control of DNA replication origin assembly regulates vertebrate development and nuclear reprogramming

    P.22 Giulio Ferrero, Turin
    Small RNA profiles in human stool reflect gut microbiome composition and together provide high accuracy to detect colorectal cancer

    P.23 Sebastian Franco Ulloa, Genoa
    Functionalized gold nanoparticles cellular uptake in the presence of various organic coatings

    P.24 Guendalina Froechlich, Naples
    Elucidation of tumor cell-expressed STING function into HSV-1 based oncolytic virotherapy

    P.25 Chiara Gabellini, Pisa
    CRISPR/Cas9-induced inactivation of the autism risk gene setd5, a putative chromatin regulator, leads to neurotransmission-associated gene alterations and social impairments in zebrafish

    P.26 Francesco Ghini, Reggio Emilia
    Context makes difference: the tumor suppressor E2F7 behaves as oncogene in undifferentiated epithelial cancers

    P.27 Sabrina Giantulli, Rome
    In vitro biological effects induced by the ultrasound-cell interaction

    P.28 Anna Maria Sole Giordano, Milan
    Generation of in vitro models of the Aicardi-Goutières Syndrome to dissect mechanisms of physiopathology

    P.29 Federico Giorgi, Bologna
    Pan-Cancer and Single-Cell modelling of genomic alterations through gene expression

    P.30 Francesca Guarino, Catania
    Human VDAC isoforms promoters: bioinformatic characterization and activity modifications in metabolic stress condition

    P.31 Jessica Guerra, Montpellier, France
    DRIP75 produces a second messenger to curb STING-dependent inflammation

    P.32 Lorena Kumarasinghe, Pozzuoli (NA)
    Understanding the pathological mechanism that leads to the cellular defects in Vici syndrome

    P.33 Hulyam Kurt, Eskişehir, Turkey
    The role of functional polymorphism located in MMP-9 gene promoter with schizophrenia patients

    P.34 Silke Lambing, Bonn, Germany
    Enhanced combinatorial efficacy of RIG-I mediated immunotherapy and radiotherapy in malignant melanoma

    P.35 Federico Lazzaro, Milan
    VID22 as a new palyer in the maintenance of genome integrity at G-quadruplex loci

    P.36 Irene Liparulo, Bologna
    Coenzyme Q depletion induces a change in chemical-physical properties of the plasma membrane

    P.37 Federica Lucini, Milan
    A novel technological approach to explore chromatin higher order structures in CD4+ T cells

    P.38 Giuseppe Madaro, Pisa
    Disentangle the link between nuclear Tau and gene expression regulation

    P.39 Alessandro Maglione, Orbassano (TO)
    Integrative analysis of -omic data reveals estrogen-responsive genomic regions in T helper cell plasticity

    P.40 Paolo Malatesta, Genoa
     Immunovirotherapy eradicates glioblastoma in a preclinical model

    P.41 Monica Mancini, Busto Arsizio
    Investigating the role of UHRF1 depletion in the sensitization to DNA damage following treatment with the DNA demethylating agent 5-aza-2’-deoxycytidine

    P.42 Marcella Manerba, Genoa
    A chemical biology approach to synthetic lethality by means of DNA repair inhibitors

    P.43 Giovanna Mangiapane, Udine
    Characterisation of APE1 paracrine function in hepatocellular cancer cells

    P.44 Chiara Marabelli, Pavia
    A tail-based mechanism drives nucleosome demethylation by the LSD2/NPAC multimeric complex

    P.45 Jessica Marinello, Bologna
    Development of new G4 binders in cancer therapy: synthesis, biophysical and biological studies of hydrazones derivatives

    P.46 Federica Marini, Milan
    The scaffold protein SLX4/FANCP plays a conserved role in early steps of homologous recombination DNA repair

    P.47 Samira Marx, Bonn, Germany
    A minimal RNA secondary structure motif mediates potent and selective activation of TLR7

    P.48 Enrico Massignani, Milan
    hmSEEKER: reliable identification of methyl-peptides from computational analysis of hmSILAC mass spectrometry data

    P.49 Valentina Menetti, Monterenzio (BO)
    Modulation of LINE-1 retrotransposition by Aicardi-Goutières Syndrome-Related RNase H2

    P.50 Giulia Miglietta, Bologna
    G4 binders as new potential immunostimulatory compounds by micronuclei induction and cGAS-STING pathway activation in human cancer cells

    P.51 Stefano Miglietta, Bologna
    MCJ/DNAJC15: role in mitochondrial metabolism of chemoresistant ovarian cancer cells

    P.52 Barbara Montanini, Parma
    New antimicrobials targeting bacterial RNA polymerase holoenzyme assembly identified with an in vivo BRET-based discovery platform

    P.53 Emanuele Monteleone, Turin
    STAT3-dependent pluripotency control via the stem-cell specific long non-coding RNA lincS1

    P.54 Sara Monticelli, Bologna
    Maximal increase of MYC to MAX expression ratio in the Drosophila eye triggers the eye to wing homeotic transformation, through deregulation of HOX genes expression

    P.55 Luisa Napolitano, Basovizza (TS)
    Human RecQ4 helicase shows DNA:RNA hybrids resolving activity

    P.56 Silvia Onesti, Trieste
    Structural insights into the evolution of the Cdc45 replication factor and its role within the  replicative helicase complex

    P.57 Francesca Orso, Turin
    miR-214 in tumor-stroma cell interactions

    P.58 Simona Paglia, Bologna
    A neurogenic model of adult brain cancer in Drosophila

    P.59 Alessandra Pagliarani, Ozzano Emilia (BO)
    Molecular clues shoulder the involvement of the mitochondrial Ca2+-activated F1FO-ATPase in the permeability transition pore

    P.60 Tito Panciera, Padua
    Mechanobiology of YAP and TAZ in physiology and disease

    P.61 Elvira Parrotta, Catanzaro
    Comprehensive proteogenomic analysis of human embryonic and induced pluripotent stem cells

    P.62 Graziano Pesole, Bari
    Characterization of expanded short tandem repeats related to genetic disorders through Oxford Nanopore Technology long read native DNA sequencing

    P.63 Sabrina Petralla, Bologna
    Proliferation/differentiation dysregulation in AGC1 deficiency brain precursor cells

    P.64 Giulia Piaggio, Rome
    Of mice and Zebrafish: shedding light for oncology research

    P.65 Ernesto Picardi, Bari
    Elucidating thousand RNA human editomes through a novel HPC REDItools algorithm

    P.67 Lorena Quirico, Turin
    Axl-148b aptamer inhibits melanoma and breast cancer tumor progression

    P.68 Cristina Renna, Milan
    The Nuclear Mitotic Apparatus protein NuMA is a mitotic dynein/dynactin adaptor

    P.69 Patrizia Romani, Padua
    Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP

    P.70 Davide Roncarati, Bologna
    Molecular characterization of the heat-shock regulatory circuit in Campylobacter jejuni

    P.71 Marco Russo, Bologna
    Innate immune response genes in human cancers: a PanCancer survey

    P.72 Erica Salvati, Rome
    TRF1 Poly ADP-ribosylation by PARP1 is required for the accomplishment of telomere replication

    P.73 Aurora Savino, Turin
    Network analysis allows to unravel breast cancer molecular features and to identify novel targets

    P.74 Stefania Scalise, Catanzaro
    In vitro model of febrile seizures in patient-specific induced pluripotent stem cells-derived neurons

    P.75 Luana Scaramuzzino, Catanzaro
    No evidence of significant differences in oocytes development and follicular fluid miRNomic profile after double stimulation in the same ovarian cycle

    P.76 Fabrizio Schipani, Milan
    Inhibiting RAD51-mediated homologous recombination for cancer therapy

    P.77 Diletta Siciliano, Naples
    Analysis of the physiological relevance of TFEB phosphorylation in vivo

    P.78 Ottavia Tartagni, Bologna
    Reproducible growth of 3D cell spheroids for drug testing

    P.79 Didem Turgut Cosan, Eskişehir, Turkey
    Changes in levels of some microRNAs of rats in enriched environment after experimental subarachnoid hemorrhage

    P.80 Marta Viggiano, Bologna
    Whole exome sequencing analysis in a twin family with ASD

    P.81 Megi Vllahu, Fisciano (SA)
    The impact of copper on host-Helicobacter interaction

    P.82 Anja Wieland, Bonn, Germany
    Identification and functional analysis of potent TLR7- and TLR8-specific RNA oligonucleotide agonists for immunotherapy

    P.83 Samuel Zambrano, Milan
    NF-κB dynamics modulates stochastic but prompt transcriptional bursts in response to inflammatory stimuli

    P.84 Annamaria Zannoni, Bologna
    Study of HP1043, the Helicobacter pylori essential transcriptional regulator

    P.85 Pasquale Zizza, Rome
    Identification of a TRF2-driven miRNA signature in colorectal cancer

    P.86 Alessandro Zuccotti, Rome
    Eukaryotic Elongation Factor 2 kinase, activated in the response to ribosomal stress, is a novel target of the oncogenic PIM1 kinase